The macaque model reveals that the disease is heavier with neoguanpi pneumonia

The macaque model reveals that the disease is heavier with neoguanpi pneumonia

Science and Technology Daily News (Reporter Zhao Hanbin) Understand the immunopropological characteristics of new crown pneumonia, which is of great significance for the prevention and treatment of neoguanpneumitis.

On November 22nd, the Science and Technology Daily reported that the study of the Kunming Institute of Sciences in the Chinese Academy of Sciences, one study found that the immunopathological mechanism of inflammatory response delayed in the elderly macaque model of neoguanpi pneumonia, or will be available for patients with neogp pneumonia New ideas. The research results have recently been published on the international journal "signal transduction and targeted therapy".

The excessive response of the immune system is considered to be one of the main pathogenesis of neoguanpiral, and the primate is a dynamic study of new coronal pneumonia pathological mechanisms. The Chinese Academy of Sciences Kunming Institute of Massage, Zheng Yongtang, the discipline, previously studied that new crown viruses were infected with Chinese macaques, showing similar pathological features similar to human patients. However, it is characterized by differently recession in timely decline in the immune response of young macaques, and the abnormal changes of the elderly macaque delayed lung tissue inflammatory response. Age-related abnormal immune microenvironment, may have been formed in the early stage of new crown virus infection, and continued to affect the progression of diseases in elderly patients.

In order to verify this hypothesis, the Zheng Yong Tang researcher team is based on multiple immunofluorescence staining quantitative techniques, and more accurate immunopropathological research on Chinese macaque neogp pneumonia models.

By analyzing the early unsatisfactory pulmonary tissue of infection, the research team found that the viral infection did not significantly affected by age, the elderly monkey and the lung tissue of the young monkey ACE2 positive cells were reduced in the infection, but the elderly macaque ACE2 positive cell apoptosis, The level of autophagy and signal pathway is more severe than young macaques.

In addition, after the elderly macaques infected with new crown viruses, the inflammatory factor secretion cells in the lung tissue increased, which provided the foundation for the inflammatory outbreak after tissue lesions.

The elderly macaque lung tissue naturally highly expresses some cytokines and interferon signal proteins, which caused immune tolerance, passivated the reaction ability of the immune system, explaining the inflammatory reaction delay characteristics of the elderly macaque model.

New crown virus infection specifically induces aggregation of elderly kiwi transmining factor CXCR3 positive cells in pulmonary, spleen and peripheral blood, is a age-related systemic pathological characteristics.

After the elderly macaque infected new crown viruses, instead of cultivating a large number of CXCR3 positive cells into the infection site, it may be one of the serious mechanisms that have changed the changes of elderly macaque lung disease.