Thousands of new brain expressions gene isomers determined

Thousands of new brain expressions gene isomers determined

By characterizing the degree of homologous isomer diversity in humans and mouse skin, a new study in the University of Exeter, UK revealed the complexity of gene expression in the brain, including identifying Alzheimerism , New isomers of disease-related genes such as autism and schizophrenia.

Studies have shown that genes expressed in human brains may result in more proteins than previously considered.

About 20,000 genes are encoded in the human DNA sequence, but each gene can be expressed by many different gene versions or isomers generated by the "selective splicing" process.

Selective splicing greatly increases the encoding complexity of the genome, and its importance is that these isomers have different functional characteristics to play a role in health and diseases.

It is known that selective splicing is particularly important in the central nervous system, and it also works in the development and function of the brain. In the study of the "Cell Report", the team led by Professor Jonathan Mill of Exetet University uses new long-read sequencing law to characterize complete transcripts, describe all differences in human and mouse brains. Forming. The isomers of about half of them were not described before, and most of these new isomers had the potential to encode protein.

The researchers said: "Isomers have a wide range of functions, selective splicing plays an important role in regulating gene functionality in the brain, and is related to many brain diseases.

Now, we first characterized different isomers in human and mouse brains, and explored the differences in the brain development.

The study determined that thousands of new brain expression isomers, confirmed the importance of selective splice in the cortex, which significantly increased transcription diversity, supporting important mechanisms in genetically regulation of brain. "Researchers said that there is significant differences in isomeric diversity of specific genes between human and mouse brains, and huge changes between fetal and adult leather also indicate an important role in selective splicing in neurological development. Jonathan Mir said : "We are pleased to find that genes associated with 3 brain diseases (Alzheimeria, autism and schizophrenia) have many new isomers previously not described. We are exploring how these isomers play a role in the illness.

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